Management of Drug Shortages with 0.9% Sodium Chloride, Sterile Water Bacteriostatic water is better when diluting any medication because it offers better solubility for the most part. 62.5 mg/mL, 3.2 mL b. A major difference between the two is the patient population. Once vials are partially stoppered, they are transported to the lyophilizer. But dont get too excited just yet. Bacteriostatic Water Vs. Sterile Water Bacteriostatic water and sterile water are essentially used for the same function which is to dissolve the drugs/medications for injecting purposes. Bacteriostatic water and sterile water can be used in intravenous, intramuscular and subcutaneous injections. Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. Sterile water is water that has no additives or preservatives added to it. Bacteriostatic water is very easy to manufacture while sterile water is an arduous process. Do NOT reuse the same saline syringe to flush VADs before and after medication administration. On the insulin syringe, 100 units correspond to 1ml, so 10 units will correspond to 0.1ml of the bacteriostatic water. Sterile water is labeled for both injections and irrigations whereas bacteriostatic water is only labeled for injections. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. Store at 20 to 25C (68 to 77F). The action you just performed triggered the security solution. For those of you thinking about the volume of water, 1ml is usually enough for all the peptides available in the market. The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. The next step is to do is add the mass of the peptide in mg that you want to reconstitute (This is generally going to be listed on the peptide vial) with the x ml of bacteriostatic water in order to get your desirable dosage in mcg. Some of the older lyophilizers cannot tolerate steam under pressure and sterilization is marginal at best. Once you have put the details, our reconstitution calculator will use its algorithm and devise the volume needed to get your peptides reconstituted! However, there are some differences between the two. This thread is archived Based on 31 documents. Some drugs for injection may be incompatible in a given vehicle, or when combined in the same vehicle or in a vehicle containing benzyl alcohol. There are only two kinds of water that are most safe to reconstitute peptides. The reconstitution process is the same for both. I'm diluting my AA (vinegar) to get to 0.6% AA. and PRECAUTIONS sections. This process is often helpful in breaking down the big solid lumps of peptides in the water and aids in the dissolution process. and ADVERSE REACTIONS. Lets explore their points of similarity and difference to understand their appropriate uses. Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results. It is a copolymer of ethylene and propylene. Providing a method for introducing the sterile moisture with uniformity may be difficult. As mentioned previously, sterile water only has distilled water and nothing else. did you ever get an answer? During peptide reconstitution, two variations of solutions are popular. It is only used for injections such as intravenous, intramuscular and subcutaneous. RxList does not provide medical advice, diagnosis or treatment. Helpful. The recommended dosage of BPC 157 is somewhere between 200mcg to 1000mcg, depending on your body weight. Avoid repeated freeze-thaw cycles: It is essential to avoid repeated freeze-thaw cycles, as they can cause damage to the peptide and decrease its stability and activity. Consult with pharmacist, if available. Data sources include IBM Watson Micromedex (updated 1 May 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Plus, peptide solutions made with bacteriostatic water resist contamination. Plus, youll feel like a mad scientist, and who doesnt love that feeling? They both are USP meaning they have an official monograph or documentation by the United States Pharmacopeia, both are not used for IV solutions. Carefully install the needle tip on a syringe. On the other hand, TB-500, another potential peptide for quick healing is usually dosed at 7.66mg per week. This bacteriostat is usually 0.9% benzyl alcohol. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. Sample 1 Sample 2 Sample 3. Experts state that it may be necessary to run trials in order to select the best solvent for various peptides, and sodium chloride water should be avoided [12]. Bacteriostatic water (BW) has a pH of about 5.7. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. Bacteriostatic Water for Injections | The A-Z Guide The choice is purely up to the user which solution to use. You should never inject bacteriostatic water without mixing in any medications because the benzyl alcohol in it causes the red blood cell lysis. Bacteriostatic water works well as a peptide solvent, reconstituting the compounds without compromising their effectiveness. Also, nothing contained on this Website shall be interpreted as advising you. More posts from r/Peptides 46K subscribers Hour_Love5645 6 days ago NSFW This method can preserve the peptides stability and activity for several months to years, depending on the peptides properties and storage conditions. All you have to do is just follow the easy steps and BOOM! Bacteriostatic waters preservative content prevents contamination for multiple doses, while sterile water may be contaminated after one use. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. There are not many side effects associated with using bacteriostatic water. Should I dilute with sterile water (USP grade) or BW? Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). Our goal is to provide you with the most scientifically accurate, unbiased, and comprehensive information regarding all research peptides and SARMs. Reconstitution. For more information, please see our Inspect reconstituted (diluted or dissolved) drugs for clarity (if soluble) and freedom from unexpected precipitation or discoloration prior to administration. In the event these should occur, re-evaluate the patient and institute appropriate corrective measures. Average normal adult daily requirement ranges from two to three liters (1.0 to 1.5 liters each for insensible water loss by perspiration and urine production). Some peptides are still off-limits to us mere mortals, and only available for research purposes. Validation of these types of filling operations should include media fills and the sampling of critical surfaces and air during active filling (dynamic conditions). publishing any Website material in any other media; selling, sublicensing and/or otherwise commercializing any Website material; publicly performing and/or showing any Website material; using this Website in any way that is or may be damaging to this Website; using this Website in any way that impacts user access to this Website; using this Website contrary to applicable laws and regulations, or in any way may cause harm to the Website, or to any person or business entity; engaging in any data mining, data harvesting, data extracting or any other similar activity in relation to this Website; using this Website to engage in any advertising or marketing. The stopper is placed on top of the vial and is ultimately seated in the lyophilizer. AOD 9604 can either be reconstituted in bacteriostatic water (BAC) or sterile water. However, when excipients or other additives are present, weight variation may be applied provided there is correlation with the sample weight and potency results. Parenteral preparations containing benzyl alcohol should not be used in epidural or spinal anesthesia procedures. In case you experience any of these side effects, you should immediately stop using sterile water for injections and talk to a doctor. In case any of the mentioned side effects are present, it is highly advisable to discontinue the use of bacteriostatic water and consult a doctor. The second step is to use your syringe and draw out 1ml of bacteriostatic water from the vial without really touching the needle as it could cause contamination. Consult the manufacturer's instructions for choice of vehicle, appropriate dilution or volume for dissolving the drugs to be injected, including the route and rate of injection. Last but not least, use plastic storage containers made up of polypropylene as it is chemically resistant and there is usually no fear of breaking/spilling as well compared to glass containers. It is used as a solvent or dilutant for drugs or therapeutic compounds that call for aqueous injection. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. Also, if you are experimenting with new peptides, it is always best to use bacteriostatic water to dilute the peptides. All rights reserved. Bacteriostatic Water may be used alone or with other medications. Now, before you start flexing your peptide muscles, you need to learn the proper way to reconstitute them. Its preservative content reduces the risk of contamination and infection, boosts shelf life, and enables optimal solvency for aqueous injection [6]. Somatropin should not be used for. Sorry Red, I was ambiguous with my 1st post. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines 3977). Bacteriostatic water has wider availability and is simpler to manufacture. I have this same question. Water for Injection, USP is chemically designated H2O. 1. : the action of reconstituting or state of being reconstituted. May contain hydrochloric acid for pH adjustment. They quickly get ruined by heating, even room temperatures, and vigorous movement. Touched on earlier, another key difference is multiple uses. Both have similar uses and are sterile but have drastically different demographics and indications. Side Effects of Bacteriostatic Water (Bacteriostatic Water for - RxList Please refer to the WARNINGS Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. There have been times when sterile water has been in short supply. Home > Peptides > Peptide Reconstitution + Mixing Guide with Calculator. Correctly reconstituting peptides is essential in their effectiveness. When diluting or dissolving drugs, mix thoroughly and use promptly. Any user ID and password you may have for this Website are confidential and you must maintain confidentiality as well. Another key difference is availability. FDA indications vary regarding drug interactions. Our content is continually monitored by an internal peer-review process to ensure accuracy. How to Properly Mix, Dose, and Store Peptides - Paradigm Peptides The proper reconstitution of HGH before injection closely follows the above method. We do the complete research and follow standards before starting the manufacturing process. This should hopefully shed some light on an easily confusing topic on which water to use. Do not store reconstituted solutions of drugs for injection unless otherwise directed by the manufacturer of the solute. Medically reviewed by Drugs.com. Sterilization procedures should parallel that of an autoclave and a typical system should include: Provisions for sterilizing the shelf support rods unless they are only exposed to the inside of the chamber after stoppering. Morgan, SL and Spotts, MR; "How to Select a Pharmaceutical Freeze-Drying System"; Pharmaceutical Technology, volume 3, No. It may be wise to always opt for bacteriostatic water if both water types are allowed for use. The most common side effects of H2Oinclude: Tell the doctor if you have any side effect that bothers you or that does not go away. Besides neonates, they both can be used for the rest of the population including pediatrics, adults and the geriatric community. We comply with the HONcode standard for trustworthy health information. (I would personally recommend bacteriostatic water because of its longer shelf-life). Now we will explore some of the most exciting applications. Both bacteriostatic water and sterile water are not used for straight injections, they have to be diluted with a drug or solvent. Sterile water usually comes in single-unit doses and the reuse of units is prohibited. Stability data should be reviewed and the justification of the expiration date should be based on batches with the higher moisture content. Both have the dangerous side effect of hemolysis when injected alone. Using either in the proper conditions can provide extraordinary results. Create your account and enjoy a new shopping experience. It is supplied in a multiple-dose container from which repeated withdrawals may be made to dilute or dissolve drugs for injection. By displaying Your Content, you grant Buckle LLC a non-exclusive, worldwide irrevocable, sub licensable license to use, reproduce, adapt, publish, translate and distribute it in any and all media. Sterile water is formulated for irrigation, such as rinsing wounds, unlike bacteriostatic water. Because different stoppering equipment is required, stoppers are sometimes placed on vials by operators rather than by machine. Statements regarding products presented on Peptides.org are the opinions of the individuals making them and are not necessarily the same as those of Peptides.org. The Bacteriostatic Water can be used in diluting drugs that can subsequently be administered by intravenous, . If the product is reconstituted with Sterile Water for Injection, USP, use immediately and discard any unused portion. But not all peptides dissolve in water easily, so it usually is recommended that you try to dissolve the peptide in any of these waters using Sonication. You are granted limited license only for purposes of viewing the material contained on this Website. Last updated on Dec 1, 2022. Both are suitable for subcutaneous intravenous, intramuscular, and intradermal injections. Now that you know the general peptide reconstitution guidelines, lets talk about some of the exceptions. So, you will need alcohol swabs, a syringe (27-29 gauge insulin needles), the lyophilized peptide that you have ordered, and the bacteriostatic water or sterile water, depending on your preference. 4 people found this helpful. With patients having the autonomy to take medications at home at their own comfort, the education on these sterile solutions is crucial. Water balance is maintained by various regulatory mechanisms. Though their features overlap, bacteriostatic water and sterile water have several significant differences. Bacteriostatic Water for Injection, USP is supplied in a multiple-dose 30 mL plastic fliptop vial (List No. May contain hydrochloric acid for pH adjustment. This information, including any referenced scientific or clinical research, is made available for educational purposes only. But, if there is an absolute need to stock solution form, what I would recommend is to store the required dosage into individual vials. Dr. Fouda uses his extensive knowledge and expertise as a neurosurgeon to medically review articles for accuracy and credibility, ensuring that the information presented is up-to-date and trustworthy. If you are interested in using bacteriostatic water for injections, look no further! The preservative agent (0.9% benzyl alcohol) in bacteriostatic water allows packaging in multi-dose vials that resist contamination for up to 28 days when used with sterile needles. Freeze-drying: Freeze-drying, also known as lyophilization, is a method that removes water from the peptide solution and allows the peptide to be stored in a stable, dry form at room temperature for an extended period. A major concern with the filling operation is assurance of fill volumes. It would seem very difficult for a manufacturer to be able to demonstrate satisfactory validation of sterilization of a lyophilizer by chemical "treatment.". Do NOT dilute or reconstitute medications by drawing up the contents into a commercially available, prefilled flush syringe of 0.9% sodium chloride and then administering the resultant product. Administration of an estimated 9 mL to a 6 kg infant or neonate is potentially capable of producing blood pressure changes. So, if you are someone who has seen the vials of both types of water, I am sure you can now understand why a bacteriostatic water vial contains considerable volume while a sterile water vial contains just a few milliliters. A mainstay in medical facilities, research labs, and beyond, bacteriostatic water resists contamination for up to 28 days after initial use. Reactions which may occur because of this solution, added drugs or the technique of reconstitution or administration include febrile response, local tenderness, abscess, tissue necrosis or infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection and extravasation. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Lets nail the major differences right from the start. After that, collect and prep your materials. Sterile water is free of any organic materials but contains inorganic materials to some extent. 420 Throckmorton Street, Suite 200, Fort Worth Texas 76102, Copyright 2022 BacteriostaticWater.com - All Rights Reserved, Wholesale Hospira Bacteriostatic Water Supplier, Need help? It is considered an ideal sterile solution due to its low toxicity and minimal interference with drug effectiveness. If you have an allergy to benzyl alcohol, discontinue or avoid bacteriostatic water and opt for sterile water. How to Use HGH: Mixing, Reconstitution, Injecting Step By Step Guide Cloudflare Ray ID: 7c0dd6108cb23fde Recent inspections have disclosed potency and sterility problems associated with the manufacture and control of lyophilized products. Once the peptide is really made soluble in any of the relevant solutions, diluting it with bacteriostatic water or sterile water is recommended. Bacteriostatic Water belongs to a class of drugs called Sterile Irrigating Solutions. For these types of products, bioburden should be minimal and the bioburden should be determined prior to sterilization of these bulk solutions prior to filling. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. Bacteriostatic water is a sterile form of water that has been brought to a pH between 4.5 to 7.0. Please enter the email address for your account. If available, sonication may be performed in order to speed up the process. Scan this QR code to download the app now. Which one to choose: Bacteriostatic Water vs. Sterile Water. There are no adverse or bad side effects of using sterile water in small doses, one should never take it intravenously. They can manage our circadian rhythms, regulate growth hormones, help with weight loss, and even make us look younger. Use only as a diluent or solvent. The site is secure. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Buckle LLC is permitted to revise these Terms at any time as it sees fit, and by using this Website you are expected to review these Terms on a regular basis. It would ideally be either 0.3ml, 0.5ml or 1ml syringe. Both may be used in the injection of peptides, hormones, and various medications, often reconstituted from lyophilized powder. Gather the following: alcohol swabs, bacteriostatic water, peptide powder, and a sterile syringe. Obviously, there is a much greater chance of contamination in this type of operation because of the involvement of people. Parenteral preparations with benzyl alcohol should not be used for fluid replacement. With the presence of 0.9% benzyl alcohol, the shelf-life of a bacteriostatic water vial is considerably increased up to 28 days as it will prevent the growth of any bacteria. There may be cases in which sterile water is more appropriate, as outlined above. corrective measures. ], Hospira, Inc., Lake Forest, IL 60045 USA. Use only as a diluent or solvent. As the title suggestswhats the difference between bacteriostatic water and reconstitution solution? Also, there should be provisions to isolate particular sections of the filling operations when low or high fills are encountered. Both substances are sterile solvents formulated for use in medical settings. Package insert / product label Reconstitution means any Securitization Transaction or Whole Loan Transfer. Deus Medicalbelieve in completing the challenges usually faced by pharmaceutical companies in India. Both act as dilutants or solvents of substances to enable injection. When you buy through links on our site, we may earn a commission. The sterilization of the lyophilizer is one of the most frequently encountered problems. False BACTERIOSTATIC WATER Rx only While you can go on to use the conventionally manual way to reconstitute peptides, it gets a whole lot easier to use the reconstitution calculator, and get the right dosage! Product Partnering is our major thrust area and to facilitate this process. Some of the important aspects of these operations include: the formulation of solutions; filling of vials and validation of the filling operation; sterilization and engineering aspects of the lyophilizer; and testing of the end product. Our focus is to exclusively link to peer-reviewed studies found on respected websites, like PubMed. What is bacteriostatic water? Archived post. This parenteral preparation is unlikely to pose a threat of fluid overload except possibly in very small infants. Daptomycin RF has a longer in-use shelf period although times vary based on dosage form (vial, IV bag, or syringe) and diluent used. Intravenous administration of Bacteriostatic Water (bacteriostatic water (bacteriostatic water for injection) for injection) for Injection without a solute may result in hemolysis. a. PT-141 can be reconstituted in bacteriostatic water (BAC) or sterile water. Contact us at info@Bacteriostaticwater.com, Bacteriostatic Water vs. Sterile Water: The Differences That Can Save Your Life. It also is prepared with a bacteriostat, a compound used to prevent any bacterial growth. Bacteriostatic Water for Injection may kill some of the vegetative cells if present as contaminants. Made with the organic preservative benzyl alcohol, this solution resists contamination to enable multiple doses per vial. The .gov means its official.Federal government websites often end in .gov or .mil. SIDE EFFECTS. It is not intended nor implied to be a substitute for professional medical advice. Typical finished product testing that should be reviewed includes dose uniformity testing, sterility testing, and any required stability testing of aged batches of reconstituted solutions. However, some of the other dosage forms that are lyophilized, such as hydrocortisone sodium succinate and methylprednisolone sodium succinate have no antibacterial effect when in solution. Bacteriostatic Water (bacteriostatic water for injection) is a highly purified, sterilized water containing 0.9% benzyl alcohol that is used to dilute or dissolve medications to the appropriate consistency for injection. Bacteriostatic water is usually the term given to a commercial preparation (made by Hospira, for example), whereas reconstitution solution is the term given by a smaller (usually underground) company that makes its own to sell. This is the method of peptide reconstitution with bacteriostatic water for injection [13]: Human growth hormone has a range of therapeutic applications, from enhanced physical composition and performance, to treatment of hormone deficiency in adolescents and children [14, 15]. Plus, it is a great dilutant for a range of drugs and therapeutic substances, facilitating aqueous delivery without compromising potency or effectiveness. The meaning of RECONSTITUTE is to constitute again or anew; especially : to restore to a former condition by adding water. Its like a chemistry experiment, but instead of blowing things up, youll be improving your health. Allow the powder to naturally dissolve until the vial is transparent. tion ()r-kn (t)-st-t (y)-shn. If I have a 2mg bottle how much water total do I put into the vial? While there is no fixed dosage of peptides and each peptide accounts for a different dose. Generally lyophilized products have short expiration dates. ZOMACTON 10 mg reconstituted with bacteriostatic water for injection containing 0.33% metacresol should not be used if the patient is allergic to metacresol. On the other hand, a sterile water vial doesnt contain any preservatives/additives which can keep it free of pathogens for a longer time, thus one will have to use it immediately after opening the seal. Peptides the proteins little brother can do wonders for our bodies! PDF SOLU-MEDROL (methylprednisolone sodium succinate for injection, USP The Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. HGH Mixing Reconstitution 1. This website is using a security service to protect itself from online attacks. Two sterile solutions that are commonly used are bacteriostatic water and sterile water. Dre Terrell Whitfield,, Fight Night Champion Legacy Mode Training Tips, John Castro David Dobrik, Articles I
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