Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Calcium and Vitamin D: Important The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. And theyll recommend if its the best option for your condition. If youre concerned about weight gain with Prolia, talk with your doctor. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. The fractures may require surgeries, take several months to heal, or both. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Some rare side effects of Prolia can be serious and need medical attention. Low blood calcium level. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. Call your doctor for medical advice about side effects. Every 6 months youll get another dose of Prolia. Learn about the different options, including the benefits of each and any potential side, A FRAX score can help predict the risk of fractures in people with osteoporosis. Is the ketogenic diet right for autoimmune conditions? Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). These are serious. Common Bone pain from Prolia may be most noticeable in your arms and legs. Generic name: denosumab (Prolia) [den-OH-sue-mab] Your dentist may have you use a chlorhexidine mouth rinse before and after surgery to reduce your risk for jaw-related side effects. if you are taking medicine that lower your blood calcium levels. With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. They can suggest ways to help relieve these side effects. The most common side effects of Prolia in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. This medicine may cause jaw bone problems (osteonecrosis). Nausea can sometimes be a symptom of severe constipation. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). 8,432 people who take Prolia and Calcium together, and have interactions are studied. This is because its not known if Prolia is safe to receive while breastfeeding. Pregnancy. You should not breastfeed while using this medicine. Heres a short list of some of the mild side effects that Prolia can cause. Prolia should not be used during pregnancy. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API). MNT is the registered trade mark of Healthline Media. If youre able to become pregnant, your doctor will have you take a pregnancy test before you start Prolia treatment. Your doctor will order blood tests to check your level before you start using Prolia and regularly during your treatment. But it can increase your risk of serious health problems, such as heart attack. To learn more about this side effect, see Side effect specifics below. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Not getting enough calcium in your diet can lead to fragile, brittle bones that are more prone to fractures and disease. If you miss a dose of Prolia, you should receive your injection as soon as you can. With arthritis, you have pain and inflammation of your joints. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Its important to discuss all your concerns with your doctor. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Your risk for some health conditions increases when you are postmenopausal. WebNow that Im taking Prolia, do I still need calcium and vitamin D? Web You will receive Prolia 1 time every 6 months. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Take good care of your teeth and gums while you receive Prolia. Continue reading. Some people who take Prolia develop severe bone, joint, or muscle pain. Before you have any dental work done, tell your dentist you are receiving this medicine. Various types of osteoporosis medications are available. Learn more about your health after menopause. Doing so will help to prevent dental problems. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. in your skin, lower stomach area (abdomen), bladder, or ear may happen. for breast cancer that has not spread to other parts of the body. Over time, Prolia can reduce bone loss and make your bones stronger. Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. If you keep this medicine at home, store it in the original carton in a refrigerator. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. Follow your doctor's instructions about any restrictions on food, beverages, or activity. They include bone pain, back pain, and a higher risk of certain infections. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. So, dont be afraid to ask questions or offer feedback on your treatment. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. These medications have different active ingredients and they belong to different groups of drugs. Prolia has active ingredients of denosumab. (Hint: it's not just. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Specifically, Prolia works by blocking a protein called RANK. Copyright 1996-2023 Cerner Multum, Inc. This is not a complete list of warnings for Prolia. Talk to your health care professional or pharmacist for more information. If youve noticed hair loss since starting Prolia treatment, talk with your doctor. WebTake calcium and vitamin D as directed by your doctor, usually 1000 milligrams of calcium and at least 400 IU of vitamin D daily. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. But if they become bothersome, talk with your doctor or pharmacist. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). You should receive your missed injection as soon as possible. Your risk for infection with Prolia may be higher if you have a weakened immune system. for prostate cancer that has not spread to other parts of the body. There are no known interactions with Prolia and other medications, supplements, or other products. Results may vary. You should always consult your doctor or another healthcare professional before taking any medication. They can also suggest ways to relieve this side effect. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines A healthcare provider will give you this injection. You should not receive Prolia if you are allergic to denosumab, or if you Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. Can you drink alcohol while taking Prolia? Usually, but it depends. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. Find out why people need calcium, which foods provide it, and what happens if they consume. Cleveland Clinic is a non-profit academic medical center. However, drinking too much alcohol may raise your risk of falling. If you develop a side effect while taking Prolia and want to tell the FDA about it, visit MedWatch. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. What Health Changes Should You Expect Postmenopause? To see a side-by-side comparison of Prolia and Fosamax, view this drug article. Store in the original container away from heat and light. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? Stopping Prolia doesnt cause withdrawal symptoms. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). Prolia isnt approved to treat osteopenia or arthritis. Talk with your doctor before starting Prolia treatment. WebIn many individuals, calcium supplements are better absorbed when taken with food. Prolia and Calcium drug interactions - eHealthMe You may report side effects to FDA at 1-800-FDA-1088. Osteoporosis Medications (Bisphosphonates) - Johns Hopkins (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Calcium Studies of Prolia didnt report weight gain as a side effect of the drug. Call your doctor at once if you have: new or unusual pain in your thigh, hip, or groin; severe pain in your joints, muscles, or bones; skin problems such as dryness, peeling, redness, itching, blisters, bumps, oozing, or crusting; or. Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. My GP (not the doctor who treats my osteoporosis) wondered if my early complete hysterectomy (I havent taken estrace in 15 years) and high dosage of thyroid I must take daily, effect the absorption of calcium? Your doctor may also recommend other treatments with Prolia to help increase your bone mass. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. Some people may have dental or jaw-related issues with Prolia use. Here are some frequently asked questions about the drugs side effects and their answers. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Prolia is a medicine that may affect the ability of your body to fight infections. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. You should also take calcium and vitamin D supplements while being What are some frequently asked questions about Prolia? Yoga is an excellent way to manage symptoms of osteoporosis. Your doctor will explain how Prolia will be given to you. * Sex and gender exist on spectrums. In rare cases, your doctor may have you self-inject Prolia at home. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. There is a potential for serious side effects to an unborn child. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. Do not share this medicine with others. Some people have developed unusual fractures in their thigh bone. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. See your dentist regularly. Brush and floss your teeth regularly while receiving this medication. Prolia You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Youll likely have questions about your condition and treatment choices. Your doctor or another healthcare professional will inject Prolia under the skin in one of the following areas: Prolia doses are given as an injection by healthcare professionals once every 6 months. They may be able to help you identify the cause. Do not treat yourself. For women with osteoporosis after menopause at high risk for fracture. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. To help prevent low calcium, your healthcare provider may also Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Your side effects from Prolia may also vary depending on your gender. They may want to check for other causes. Using Prolia for Bone Loss in People With Breast Cancer People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. But hair loss has been reported by people who have taken Prolia since then. They can also tell you about other treatment options available for osteoporosis and bone loss prevention. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. A biologic drug is made from parts of living organisms. Prolia works by blocking osteoclasts (certain bone cells) from breaking down bone tissue in your body. Bone density decreases with time, and some people have a risk of developing weak or brittle bones. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Weakness and tingling can also occur. Prolia can cause both mild and serious side effects. This makes your bones weak and increases your risk for bone fractures or breaks. If you have any questions about Prolias side effects, talk with your doctor. Although very rare, Prolia can cause serious dental problems and jaw-related side effects. If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. All rights reserved. What should I know about Prolia vs. Fosamax? Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. 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